Have you been dying to interrogate carefully curated biomedical knowledge using LLMs? We just made it possible! In this post, we show you how you can access the wealth of information captured in the Monarch Initiative Knowledge Graph, using our ChatGPT integration via the plugins feature from OpenAI. What does AI know? Artificial Intelligence…

The Monarch Initiative is a leader in essential global standards for biomedical research and semantic data integration technologies. Our initial goal was to leverage “all the phenotype data” from across organisms and sources to improve rare disease diagnostics. Over the years, this mission has expanded and Monarch resources and integrated…

The GA4GH Phenopacket schema, designed by members of the Monarch Initiative and Phenomics First CEGS teams within the GA4GH Clin/Pheno workstream, is a widely-used standard for sharing disease and phenotype information that characterizes an individual person or biosample. It standardizes the collection and exchange of phenotypic and other clinical data…

Dr. Nicolas (Nico) Matentzoglu, an invaluable semantic engineer in the Monarch team, is the recipient of the 2023 International Society for Biocuration (ISB) Excellence in Biocuration Advanced Career Award, which recognizes his important contributions to the field of biocuration. The ISB is a professional society for biocurators, ontologists, developers and…

For rare disease patients, limited drug treatments are available and research on specific diseases is often scarce. Improving access to drug treatments or repurposing existing drugs is a high priority for rare disease clinicians and researchers. The Critical Path Institute (C-Path) is a biomedical non-profit partnered with the FDA to…

The Monarch Initiative, led by team captain Monica Munoz-Torres, Ph.D., Associate Professor of Biomedical Informatics at the University of Colorado School of Medicine, was awarded a Distinguished Achievement Award for Data Reuse in the first NIH DataWorks! Prize in February 2023. The DataWorks! …

Large Language Models (LLMs) such as GPT-3+ can help with tasks ranging from generating sophisticated software to writing love sonnets. We wondered whether we could harness the power of LLMs to facilitate a difficult hands-on task that we often encounter: assisting in the curation of a structured knowledge base that…

With the aim of improving diagnosis and, ultimately, treatment, the Monarch Initiative and the Phenomics First Center of Excellence in Genomic Science (CEGS) bring together basic science knowledge, clinical research and rare disease patients to help untangle the causes and characteristics of rare diseases. There are more than 10,000 different…

We at the Monarch Initiative are excited to announce that we have been awarded a Distinguished Achievement Award for Data Reuse in the first NIH DataWorks! Challenge, which awarded 11 prizes out of a total field of 106 applicants. Monica Munoz-Torres, Ph.D., …